We don't hide behind vague claims or trace amounts. Every active in every Dermalune formula is here — with the clinical mechanism that makes it work.
Microencapsulated retinoic acid precursor with time-release delivery — converts to active all-trans retinoic acid via intracellular esterases without peak irritation
Identical to skin-native ceramide 2 — integrates into the stratum corneum lipid matrix to fill intercellular gaps
Inhibits melanosome transfer, upregulates ceramide synthesis, suppresses inflammatory cytokines
Madecassoside and asiaticoside bind to TGF-β receptors to upregulate collagen I and III production and inhibit inflammatory mediators
Triterpene glycoside that inhibits TNF-α and IL-6 production while activating VEGF for improved microcirculation
High molecular weight ferment polymer forms a moisture-retaining film on the skin surface while inhibiting hyaluronidase (the enzyme that breaks down natural hyaluronic acid)
Fully saturated analogue of skin-native squalene — does not oxidize, non-comedogenic, integrates seamlessly into sebum to reinforce the acid mantle
Bifida ferment lysate and lactococcus ferments deliver metabolites that modulate immune response and feed beneficial skin bacteria
Oat-derived polysaccharide activates macrophage receptors to accelerate wound healing cascade and inhibit histamine release from mast cells
Lipid-soluble beta hydroxy acid that penetrates sebaceous follicles to dissolve the plug of oxidized sebum and dead keratinocytes causing congestion
Activates matrix Gla protein (MGP) which prevents calcium deposits in elastin — improves vessel elasticity and reduces the hemoglobin oxidation visible as dark under-eye circles
Zinc ions inhibit 5-alpha reductase (the enzyme that converts testosterone to sebum-stimulating DHT) and exhibit bacteriostatic activity against C. acnes